Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies
نویسندگان
چکیده
منابع مشابه
compactifications and function spaces on weighted semigruops
chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...
15 صفحه اولTritium Radiolabelled Antisense Oligonucleotides for ADME Studies
K. Webbley, S. Harris, J. Bloom, C. Henson, V. Wilson, C. Hawes, D. Price, J. Haffenden Pharmaron, Inc. Purpose Antisense Oligonucleotides (ASO), continue to elicit interest as novel therapeutic agents designed to specifically and selectively inhibit the production of various disease related gene products. For efficacy to occur, the therapeutic material must reach the site of action in quantiti...
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Nucleic acids are becoming increasingly important as therapeutic molecules mainly for the ease with which specificity for a vast range of targets of these drugs is achieved. Yet the dose rates of several mg/kg are not easy to provide. Reform of drug policy has been suggested earlier to facilitate newer therapeutic strategies to be put to use. With the current technology, each mg of the unmodifi...
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1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
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ژورنال
عنوان ژورنال: Journal of Pharmacological and Toxicological Methods
سال: 2014
ISSN: 1056-8719
DOI: 10.1016/j.vascn.2013.10.005